Spybot - Search & Destroy
Spybot - Search & Destroy supports the Windows Accessibility API to automatically detect whether any screen reader or other software helping optically handicaped users is currently in use. In case that state is not available, e.g. because the software is not communicating with the Windows Accessibility API itself, you can specify /blinduser to manually enable the integrated support.
This support consists mostly of additional main menu items and submenus that will mirror actions that are otherwise available in toolbars (which are not reachable by using the tab key on the keyboard) or popup menus (which usually would require a click of the right mouse button).